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Literature summary extracted from

  • Casilag, F.; Lorenz, A.; Krueger, J.; Klawonn, F.; Weiss, S.; Haeussler, S.
    The LasB elastase of Pseudomonas aeruginosa acts in concert with alkaline protease AprA to prevent flagellin-mediated immune recognition (2016), Infect. Immun., 84, 162-171 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.26 extracellular
-
 Pseudomonas aeruginosa
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.26 flagellin + H2O Pseudomonas aeruginosa the enzyme is capable of degrading exogenous flagellin under calcium-replete conditions and prevents flagellin-mediated immune recognition ?
-
 ?
3.4.24.26 flagellin + H2O Pseudomonas aeruginosa UCBPP-PA14 the enzyme is capable of degrading exogenous flagellin under calcium-replete conditions and prevents flagellin-mediated immune recognition ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.26 Pseudomonas aeruginosa Q02RJ6
-
-
3.4.24.26 Pseudomonas aeruginosa UCBPP-PA14 Q02RJ6
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.24.26 proteolytic modification LasB is produced as a precursor protein that requires autocatalytic processing to ensure proper folding as it is exported across the outer membrane. Ca2+ is needed either for efficient transcription of lasB or during the process of folding and export, as calcium plays a role in the structural integrity of LasB Pseudomonas aeruginosa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.26 flagellin + H2O the enzyme is capable of degrading exogenous flagellin under calcium-replete conditions and prevents flagellin-mediated immune recognition Pseudomonas aeruginosa ?
-
 ?
3.4.24.26 flagellin + H2O the enzyme is capable of degrading exogenous flagellin under calcium-replete conditions and prevents flagellin-mediated immune recognition Pseudomonas aeruginosa UCBPP-PA14 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.26 ealastase LasB
-
 Pseudomonas aeruginosa

Expression

EC Number Organism Comment Expression
3.4.24.26 Pseudomonas aeruginosa it is possible that the induction of LasB production is increased by the combined regulatory activities of the Las and Rhl systems in a manner not applicable to AprA up

General Information

EC Number General Information Comment Organism
3.4.24.26 physiological function virulence factor Pseudomonas aeruginosa